a case-control study of the association between serum copper level and febrile seizures in children

how to cite this article: mahyar a, ayazi p, dalirani r, bakhtiyari h, daneshi khohan mm, javadi a. a case-control study of the association between serumcopper level and febrile seizures in children. iranian journal of child neurology 2012;6(1):23-28. objective febrile seizures are the most common cause of seizure in children. identification of risk factors is very important. this study was conducted to determine the association between the serum copper level and simple febrile seizure in children. materials & methods in this study, 30 children with simple febrile seizures (case group) were compared with 30 children with febrile illness without seizures (control group) regarding serum copper level. this study was conducted in qazvin children’s hospital (qazvin, iran). results the mean serum copper levels in the case and control groups were 141.41±30.90 and 129.43±18.97 mcg/dl, respectively. this difference was not significant statistically. conclusion this study revealed that there is no association between serum copper levels and febrile seizures. it seems that copper deficiency is not a risk factor for febrile seizures in children. references 1. mikati ma. febrile seizures in: kliegman rm, stanton bf, gemeiii jws, schor nf, behrman re. nelson textbookof pediatrics.19th edition. philadelphia: saunders; 2011.p. 2017-19. 2. ferrie c, newton r, martland t. febrile seizure in:mclntosh n, helms pj, smyth rl, logan s. forfar& arneils textbook of pediatrics, london: churchilllivingstone; 2008. p. 860-1. 3. mahyar a, ayazi p, fallahi m, javadi a.risk factors ofthe first febrile seizures in iranian children. int j pediatr2010;2010:862897.[epub 2010 jun 24]. 4. siqueira lf. febrile seizures: update on diagnosisand management. rev assoc med bras 2010 jul-aug;56(4):489-92. 5. daoud a, batieha a. iron status a possible risk factor forthe first seizure. epilepsy 2002;43(7):740-43. 6. hartfield ds, tan j, yager jy, rosychuk rj, spadyd, haines c, et al. the association between irondeficiency and febrile seizures in childhood. clin pediatr(phila) 2009;48(4):420-6. 7. vaswani rk, dharaskar pg, kulkarni s, ghosh k. irondeficiency as a risk factor for first febrile seizure. indianpediatr 2010;47(5):437-9. 8. amiri m, farzin l, moassesi me, sajadi f. serum traceelement levels in febrile convulsion. biol trace elem res2010;135(1-3):38-44. 9. ganesh r, janakiraman l, meenakshi b. serum zinclevels are low in children with simple febrile seizurescompared with those in children with epileptic seizuresand controls. ann trop paediatr 2011;31(4):345-9. 10. mahyar a, ayazi p, fallahi m, javadi a.correlationbetween serum selenium level and febrile seizures. pediatrneurol 2010;43(5):331-4. 11. anderson jb. copper in: mahan kl, stump se. krause,sfood, nutrition,& diet therapy 9th ed, phila, saunders;2004:150-4. 12. gaggelli e, kozlowski h, valensin g. copperhomeostasis and neurodegenerative disorders. chem rev2006;106:1995-2044. 13. lazarchick j. update on anemia and neutropenia incopper deficiency. curr opin hematol 2012 ;19(1):58-60. 14. zatta p, frank a. copper deficiency and neurologicaldisorders in man and animals, brain res rev2006;54(1):19-23. 15. tapiero h, townsend dm, tew kd. trace elementsin human physiology and pathology. copper. biomedpharmacother 2003;57(9):386-98. 16. prasad r, singh a, das bk, upadhyay rs,singh tb,mishra op. cerebrospinal fluid and serum zinc, copper,magnesium and calcium levels in children withidiopathic seizure. jcdr 2009;3(6):1841-6. 17. sholomo s. febrile seizures in: swaiman kf, ashwal s,ferriero dm. pediatric neurology: principles and practice.4th ed. philadelphia: mosby; 2006. p. 1079-86. 18. ashrafi mr, shabanian r, abbaskhanian a, nasiriana, ghofrani m, mohammadi m, et al. selenium andintractable epilepsy: is there any correlation? pediatrneurol 2007;36(1):25-9. 19. shenkin a, baines m, fell gs, lyon tdg. vitaminsand trace elements in: burtis ca, ashwood er, brunsde. tietz textbook of clinical chemistry and moleculardiagnostics. 4th ed. phila: wb saunders, 2006:1126-30. 20. mishra op, singhal d, upadhyay rs, prasad r, etal. cerebrospinal fluid zinc, magnesium, copper andgamma-aminobutyric acid levels in febrile seizures. jpn2007;5(1):39-44. 21. wu j, ricker m, muench j. copper deficiency as causeof unexplained hematologic and neurologic deficits inpatient with prior gastrointestinal surgery.j am boardfam med 2006;19(2):191-4. 22. ilhan a, özerol e, güleç m, bünyamin isik b, ilhann, ilhan n, et al. the comparison of nail and serumtrace elements in patients with epilepsy and healthysubjects . prog neuropsychopharmacol biol psychiatry2004;289(1):99-104.